Smoking and alcohol intake are major risk factors in head and neck squamous cell carcinomas Digital Subscription (HNSCCs).Although the link between TP53 mutation and smoking has been well established, very little is known about the link between acquired uniparental disomy (aUPD) and smoking and/or alcohol consumption or other clinical characteristi
Immune Checkpoint Inhibitors and Glioblastoma: A Review on Current State and Future Directions
Abstract: Glioblastoma (GBM) is the most prevalent malignant tumor of the central nervous system.The prognosis of GBM is grim, with a median overall survival of 14.6 months and only 6.9% of patients surviving 5 years after the initial diagnosis.Despite poor outcomes, standard therapy of surgical resection, radiotherapy, chemotherapy, and tumor-trea